| Date | Opponent | W/L | Score |
| Jan. 3, 1927 | Alumni Stars | W | 67-25 |
| Jan. 5, 1927 | Missouri-Columbia | L | 20-40 |
| Jan. 11, 1927 | Kemper | W | 41-10 |
| Jan. 14, 1927 | Culver-Stockton | W | 50-33 |
| Jan. 20, 1927 | Southeast Missouri | W | 31-28 |
| Jan. 21, 1927 | Southeast Missouri | L | 22-26 |
| Jan. 22, 1927 | at St. Louis University | W | 31-26 |
| Jan. 31, 1927 | Southwest Missouri | L | 17-26 |
| Feb. 2, 1927 | Southwest Missouri | W | 26-24 |
| Feb. 4, 1927 | at Central Missouri | W | 29-21 |
| Feb. 5, 1927 | at Central Missouri | L | 27-37 |
| Feb. 7, 1927 | at Southwest Missouri | L | 29-39 |
| Feb. 11, 1927 | Northwest Missouri | W | 25-23 |
| Feb. 12, 1927 | Northwest Missouri | W | 37-23 |
| Feb. 17, 1927 | Southeast Missouri | L | 17-29 |
| Feb. 19, 1927 | Central Missouri | W | 34-27 |
| Feb. 28, 1927 | Chillicothe Business College | W | 38-21 |
| March 1, 1927 | Northwest Missouri | W | 27-21 |
| March 2, 1927 | Missouri Western | W | 29-24 |
Home games in bold. | |||