| Date | Opponent | W/L | Score |
| Dec. 5, 1940 | Central (Iowa) | W | 52-28 |
| Dec. 11, 1940 | Kirksville Osteopathic College | L | 41-42(2ot) |
| Dec. 13, 1940 | at Dubuque University | W | 30-26 |
| Dec. 14, 1940 | at Upper Iowa | W | 55-28 |
| Dec. 16, 1940 | at South Dakota State | W | 41-30 |
| Dec. 18, 1940 | at Minn-Duluth | W | 42-24 |
| Dec. 20, 1940 | at Wisconsin-Superior | W | 52-49 |
| Dec. 22, 1940 | at Caledonia (Ind.) | W | 63-30 |
| at Keokuk (Iowa) Tournament | |||
| Jan. 3, 1941 | vs. Dubuque University | L | 31-43 |
| Jan. 4, 1941 | vs. Upper Iowa | W | 59-42 |
| Jan. 4, 1941 | vs. Carthage | W | 51-34 |
| Jan. 9, 1941 | Missouri-Rolla | W | 46-29 |
| Jan. 11, 1941 | at Missouri Valley | L | 41-45 |
| Jan. 15, 1941 | Northwest Missouri | L | 35-36 |
| Jan. 20, 1941 | at Southwest Missouri | W | 40-23 |
| Jan. 21, 1941 | at Central Missouri | L | 23-46 |
| Jan. 25, 1941 | Southeast Missouri | W | 37-35 |
| Jan. 27, 1941 | Missouri Valley | W | 42-38 |
| Date Unknown | Southeast Missouri | W | 31-27 |
| Feb. 2, 1941 | Missouri-Rolla | W | 42-27 |
| Feb. 4, 1941 | Kirksville Osteopathic College | W | 38-28 |
| Feb. 6, 1941 | Central Methodist | W | 45-27 |
| Feb. 14, 1941 | at Northwest Missouri | L | 29-36 |
| Feb. 21, 1941 | Central Missouri | W | 30-39 |
| Feb. 24, 1941 | Southwest Missouri | W | 43-33 |
Home games in bold. | |||