| Date | Opponent | W/L | Score |
| Dec. 1, 1965 | Nebraska-Omaha | L | 54-65 |
| Dec. 2, 1965 | at SIU-Carbondale | L | 49-91 |
| Dec. 4, 1965 | at Loyola (Ill.) | L | 79-120 |
| Dec. 10, 1965 | Northwest Missouri | L | 58-63 |
| Dec. 11, 1965 | Northern Iowa | L | 70-74 |
| Dec. 13, 1965 | at Parsons (Iowa) | L | 69-74 |
| Dec. 15, 1965 | at Lincoln | L | 83-115 |
| Dec. 21, 1965 | at William Jewell | W | 72-69 |
| at Quincy (Ill.) Tournament | |||
| Dec. 28, 1965 | vs. Georgetown (Ky.) | W | 81-79 |
| Dec. 29, 1965 | vs. Carson-Newman | L | 55-68 |
| Dec. 30, 1965 | vs. Quincy (Ill.) | L | 53-54 |
| Jan. 3, 1966 | Parsons (Iowa) | W | 78-64 |
| Jan. 8, 1966 | at Missouri-Rolla | W | 68-51 |
| Jan. 10, 1966 | at Southeast Missouri | L | 54-62 |
| Jan. 15, 1966 | at Northwest Missouri | L | 60-62 |
| Jan. 18, 1966 | at Western Illinois | W | 69-63 |
| Jan. 22, 1966 | Lincoln | W | 93-77 |
| Jan. 29, 1966 | Missouri-Rolla | L | 80-90 |
| Jan. 31, 1966 | Southeast Missouri | L | 78-84 |
| Feb. 5, 1966 | at Central Missouri | L | 47-64 |
| Feb. 7, 1966 | at Southwest Missouri | L | 68-88 |
| Feb. 12, 1966 | Central Missouri | L | 92-95 |
| Feb. 14, 1966 | Southwest Missouri | L | 67-73 |
Home games in bold. | |||