| Date | Opponent | W/L | Score |
| Nov. 21, 1980 | Central Arkansas | L | 57-59 |
| Dec. 2, 1980 | at Western Illinois | L | 74-88 |
| Dec. 6, 1980 | Central (Iowa) | W | 74-59 |
| Dec. 11, 1980 | at Quincy (Ill.) | W | 71-70 |
| Dec. 13, 1980 | Lincoln (Mo.) | W | 90-64 |
| Dec. 16, 1980 | Eastern Illinois | L | 76-78 |
| Jan. 3, 1981 | at Millikin (Ill.) | W | 60-47 |
| Jan. 8, 1981 | Washburn (Kan.) | L | 64-65 |
| Jan. 10, 1981 | at Southeast Missouri State | L | 76-83 |
| Jan. 12, 1981 | at Central Missouri State | L | 76-81 |
| Jan. 15, 1981 | at Missouri-St. Louis | L | 84-86 |
| Jan. 17, 1981 | Southeast Missouri State | W | 96-81 |
| Jan. 19, 1981 | Missouri-Rolla | W | 76-71 |
| Jan. 21, 1981 | Marycrest (Iowa) | W | 81-68 |
| Jan. 24, 1981 | at Lincoln (Mo.) | L | 59-63 |
| Jan. 27, 1981 | Grand View (Iowa) | W | 104-99 |
| Jan. 31, 1981 | Northwest Missouri State | W | 59-58 |
| Feb. 2, 1981 | Western Illinois | W | 79-69 |
| Feb. 5, 1981 | Quincy (Ill.) | W | 63-58 |
| Feb. 7, 1981 | Central Missouri State | L | 72-73 |
| Feb. 9, 1981 | Southwest Missouei State | W | 69-68 |
| Feb. 12, 1981 | Missouri-St. Louis | L | 52-54 |
| Feb. 14, 1981 | at Missouri-Rolla | W | 94-92 |
| Feb. 16, 1981 | at Southeast Missouri State | W | 65-59 |
| Feb. 19, 1981 | at Northwest Missouri State | W | 63-61 |
| Feb. 24, 1981 | Northwest Missouri State | W | 85-73 |
| Feb. 26, 1981 | at Central Missouri State | W | 71-66 |
| Feb. 28, 1981 | at Lincoln (Mo.) | W | 81-65 |
| at NCAA Division II South Central Regional (Jacksonville, Ala.) | |||
| March 5, 1981 | vs. Jacksonville State | W | 82-78 |
| March 6, 1981 | vs. North Alabama | L | 59-63 |
Home games in bold. | |||