| Date | Opponent | Result | Score | Truman Goal Scorers | Keeper (Saves) |
| Sept. 4 | at Drury | L | 0-1 | None | Leah Hollcroft (1) |
| Sept. 6 | at Missouri-Rolla | W | 3-0 | Stephanie Barrowcough (2), Amy Mangels |
Hollcroft (1) |
| Sept.12 | at Bellarmine | W | 5-0 | Barrowclough (2), Mangels, Kathy Smock, Bridgit Garthe |
Hollcroft (3) |
| Sept. 13 | at St. Joseph's | L | 1-3 | Mangels | Hollcroft (3) |
| Sept. 18 | Missouri-St. Louis | L | 1-2 | Shelly Landa | Hollcroft (7) |
| Sept. 19 | SIU-Edwardsville | L | 1-2 | Garthe | Cathy Bussjaeger (3) |
| Sept. 26 | U.S. Air Force | W | 4-3 | Trishia Harting (3), Barrowclough | Hollcroft (15) |
| Oct. 6 | at Park | L | 0-6 | None | Hollcroft (13) |
| Oct. 9 | Southwest Baptist | W | 12-0 | Tiernan Fehling (2), Harting(2), Smock (2), , Amy Zander (2), Garthe, Mangels, Lauren Jaggers, Keryi Wickenhauser |
Hollcroft (0) |
| Oct. 15 | at Queens | L | 0-2 | None | Hollcroft (7) |
| Oct. 17 | at Elon | L | 0-1 | None | Hollcroft (7) |
| Oct. 23 | Metro State | L | 0-5 | None | Hollcroft (7) |
| Oct. 27 | at Quincy | L | 1-2 | Landa | Hollcroft (8) |
| Oct. 29 | at Northern Illinois | L | 2-5 | Mangels, Harting | Hollcroft (12) |
| Oct. 30 | at Lewis | L | 0-5 | None | Hollcroft (1) |